Artigos Effects of Water Deprivation on Renal Hydroelectrolytic Excretion in Chronically Trypanosoma Cr Í/z/-infected Rats

The effect o f an 8 hour-period o f water deprivation on flu id and electrolyte renal excretion was investigated in male Wistar rats infected with the strain São Felipe (12SF) o/Trypanosoma cruzi, in comparison with age and sex matched non-infected controls. The median percent reductions in the urinary flow (-40% v -63%) and excretion ofsodium (-57% v-79% ) were smaller in chagasic than in control rats, respectively. So, chagasic rats excreted more than controls. On the other hand, the median percent decrement in the clearance o f creatinine was higher in chagasic (-51%) than in controls (-39%). Thus, chagasic rats showed some disturbed renal hydroelectrolytic responses to water deprivation, expressed by smaller conservation, or higher excretion o f water and sodium in association with smaller glomerularfiltration rate. This fac t denoted an elevation in the fractional excretion o f sodium and water.